COVID-19: Time to embrace MDI+ valved-holding chambers!

AeroChamber* Brand of Valved Holding Chambers

Dead space variability of face masks for valved holding chambers.

BACKGROUND Valved holding chambers with masks are commonly used to deliver inhaled medications to young children with asthma. Optimal mask properties such as their dead space volume have received little attention. The smaller the mask the more likely it is that a greater proportion of the dose in the VHC will be inhaled with each breath, thus speeding VHC emptying and improving overall aerosol ...

How to compare two different metered-dose inhaler-valved holding chambers in the administration of salbutamol.

D lco and the D lco VA ratio change with lung volume as would be expected with changes in surface area for diffusion. Percent predicted for D lco adjusted for lung volume (D aco ) and D lco VA ratio adjusted for lung volume (K aco ) also should be reported, using the following equations: D aco predicted 5 D lco predicted 3 (0.58 1 0.42 3 VA VAtlc) and K aco predicted 5 K co predicted 3 (0.42 1 ...

Equivalence Evaluation of Valved Holding Chambers (VHCs) with Albuterol Pressurized Metered Dose Inhaler (pMDI)

Valved holding chambers (VHCs) are medical devices that are recommended by International Asthma and Chronic Obstructive Pulmonary Disease (COPD) Guidelines [1, 2] to be used with pressurized metered dose inhalers (pMDI) as a delivery system. VHCs are designed to improve medication delivery, reduce oropharyngeal deposition of medication by substantially changing the aerodynamic particle size dis...

The Bioavailability of Salbutamol in Urine via Volumatic and Nonvolumatic Valved Holding Chambers

PURPOSE Pressurized metered dose inhalers are commonly used in patients with asthma. However, the need to coordinate inhalation with inhaler actuation means that they are not suitable for use per se. Valved holding chamber devices were developed to overcome some of the problems of pressurized metered dose inhalers. Several types of holding chambers of different sizes are available in Iran. This...